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Article

Allogeneic CD4+CD25high T cells regulate obliterative bronchiolitis of heterotopic bronchus allografts in both porcinized and humanized mouse models.

Transplantation - 1 Mar 2015

Sommer Wiebke, Knöfel Ann-Kathrin, Madrahimov Nodir, Avsar Murat, Jonigk Danny, Salman Jawad, Dreckmann Karla, Jansson Katharina, Salguero Gustavo, Maus Ulrich A, Welte Tobias, Haverich Axel, Warnecke Gregor

Abstract excerpt

BACKGROUND: Bronchiolitis obliterans syndrome is caused by a fibroproliferative process in lung allografts resulting in irreversible damage. In this study, we induced obliterative bronchiolitis and studied the contribution of regulatory T cells to its development in immune-deficient mice receiving heterotopic porcine bronchus transplants, and major histocompatibility complex-mismatched porcine peripheral blood...

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PMID: 25695787
DOI: 10.1097/TP.0000000000000632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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