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Article

Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment.

Archives of oral biology - 1 Jan 2016

Kondo Hiroko, Kurahashi Minori, Mori Daisuke, Iinuma Mitsuo, Tamura Yasuo, Mizutani Kenmei, Shimpo Kan, Sonoda Shigeru, Azuma Kagaku, Kubo Kin-ya

Abstract excerpt

BACKGROUND AND OBJECTIVE: Teeth are crucial, not only for mastication, but for overall nutrition and general health, including cognitive function. Aged mice with chronic stress due to tooth loss exhibit impaired hippocampus-dependent learning and memory. Exposure to an enriched environment restores the reduced hippocampal function. Here, we explored the effects of an enriched environment on learning deficits and...

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PMID: 26476746
DOI: 10.1016/j.archoralbio.2015.10.006

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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