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Article

Tooth loss induces memory impairment and neuronal cell loss in APP transgenic mice.

Behavioural brain research - 1 Sept 2013

Oue Hiroshi, Miyamoto Yasunari, Okada Shinsuke, Koretake Katsunori, Jung Cha-Gyun, Michikawa Makoto, Akagawa Yasumasa

Abstract excerpt

Tooth loss is a known risk factor of Alzheimer's disease (AD). However, the association of tooth loss with the molecular pathogenesis of AD is still unknown. The hypothesis that the molecular pathogenesis of AD is enhanced by molar tooth loss was tested. Seventeen female transgenic mice (J20) were divided into the experimental (EX, n=10) and control (C, n=7) groups. In the EX group, maxillary bilateral molar...

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Source

Identifiers

PMID: 23773908
DOI: 10.1016/j.bbr.2013.06.015

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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