Article
A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients.
Genome medicine - 16 Oct 2015
Pongor Lőrinc, Kormos Máté, Hatzis Christos, Pusztai Lajos, Szabó András, Győrffy Balázs
Abstract excerpt
BACKGROUND: The use of somatic mutations for predicting clinical outcome is difficult because a mutation can indirectly influence the function of many genes, and also because clinical follow-up is sparse in the relatively young next generation sequencing (NGS) databanks. Here we approach this problem by linking sequence databanks to well annotated gene-chip datasets, using a multigene transcriptomic fingerprint...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.