Article
A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers.
PLoS genetics - 1 Oct 2015
Benton Miles C, Lea Rodney A, Macartney-Coxson Donia, Hanna Michelle, Eccles David A, Carless Melanie A, Chambers Geoffrey K, Bellis Claire, Goring Harald H, Curran Joanne E, Harper Jacquie L, Gibson Gregory, Blangero John, Griffiths Lyn R
Abstract excerpt
Multiphenotype genome-wide association studies (GWAS) may reveal pleiotropic genes, which would remain undetected using single phenotype analyses. Analysis of large pedigrees offers the added advantage of more accurately assessing trait heritability, which can help prioritise genetically influenced phenotypes for GWAS analysis. In this study we performed a principal component analysis (PCA), heritability (h2)...
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