Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-phenotype genome-wide association studies of the Norfolk Island isolate implicate pleiotropic loci involved in chronic kidney disease.

Scientific reports - 30 Sept 2021

Tran Ngan K, Lea Rodney A, Holland Samuel, Nguyen Quan, Raghubar Arti M, Sutherland Heidi G, Benton Miles C, Haupt Larisa M, Blackburn Nicholas B, Curran Joanne E, Blangero John, Mallett Andrew J, Griffiths Lyn R

Abstract excerpt

Chronic kidney disease (CKD) is a persistent impairment of kidney function. Genome-wide association studies (GWAS) have revealed multiple genetic loci associated with CKD susceptibility but the complete genetic basis is not yet clear. Since CKD shares risk factors with cardiovascular diseases and diabetes, there may be pleiotropic loci at play but may go undetected when using single phenotype GWAS. Here, we used...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Loci
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Melanesia

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Share to Renal Insufficiency, Chronic

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 34593906
DOI: 10.1038/s41598-021-98935-4
PMCID: PMC8484585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-phenotype genome-wide association studies of the Norfolk Island isolate implicate pleiotropic loci involved in chronic kidney disease.PMID 34593906Read ↗

A Phenomic Scan of the Norfolk Island Genetic Isolate Identifies a Major Pleiotropic Effect Locus Associated with Metabolic and Renal Disorder Markers.Semantic proximity Read ↗

Discovering Novel Loci of Chronic Kidney Disease via Principal Component Analysis-Based Multiple-Trait Genome-Wide Association Study.Semantic proximity Read ↗

Genome-Wide Association Studies of CKD and Related Traits.Semantic proximity Read ↗

A multi-phenotype approach implicates<i>SH2B3</i>in the genetics of chronic kidney diseaseSemantic proximity Read ↗

Chronic kidney disease: novel insights from genome-wide association studies.Semantic proximity Read ↗

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.Semantic proximity Read ↗

New loci associated with kidney function and chronic kidney diseaseSemantic proximity Read ↗

A clustering approach to improve our understanding of the genetic and phenotypic complexity of chronic kidney disease.Semantic proximity Read ↗

A clustering approach to improve our understanding of the genetic and phenotypic complexity of chronic kidney diseaseSemantic proximity Read ↗

Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants.Semantic proximity Read ↗

Novel insights from genetic and epigenetic studies in understanding the complex uraemic phenotype.Semantic proximity Read ↗

A clustering approach to improve our understanding of the genetic and phenotypic complexity of chronic kidney diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.