Article
Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study.
Scientific reports - 29 Nov 2019
Chittoor Geetha, Haack Karin, Balakrishnan Poojitha, Bizon Christopher, Laston Sandra, Best Lyle G, MacCluer Jean W, North Kari E, Umans Jason G, Franceschini Nora, Prasad Gauri, Macias-Kauffer Luis, Villarreal-Molina Teresa, Bharadwaj Dwaipayan, Canizales-Quinteros Samuel, Navas-Acien Ana, Cole Shelley A, Voruganti V S
Abstract excerpt
While studies have reported genetic loci affecting serum urate (SU) concentrations, few studies have been conducted in minority populations. Our objective for this study was to identify genetic loci regulating SU in a multigenerational family-based cohort of American Indians, the Strong Heart Family Study (SHFS). We genotyped 162,718 single nucleotide polymorphisms (SNPs) in 2000 SHFS participants using an...
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