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Article

The role of genetic factors in patients with hepatocellular carcinoma and iron overload - a prospective series of 234 patients.

Liver international : official journal of the International Association for the Study of the Liver - 1 May 2016

Funakoshi Natalie, Chaze Iphigénie, Alary Anne-Sophie, Tachon Gaëlle, Cunat Séverine, Giansily-Blaizot Muriel, Bismuth Michael, Larrey Dominique, Pageaux Georges-Philippe, Schved Jean-François, Donnadieu-Rigole Hélène, Blanc Pierre, Aguilar-Martinez Patricia

Abstract excerpt

BACKGROUND & AIMS: Iron overload (IO) in HFE-related hereditary haemochromatosis is associated with increased risk of liver cancer. This study aimed to investigate the role of other genes involved in hereditary IO among patients with hepatocellular carcinoma (HCC). METHODS: Patients with HCC diagnosed in our institution were included in this prospective study. Those with ferritin levels ≥300 μg/L (males) or ≥200...

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Identifiers

PMID: 26474245
DOI: 10.1111/liv.12984

Genes

HFE
HAMP
GNPAT
HJV
TFR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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