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Article

Genome-Wide Methylation Study Identifies an IL-13–induced Epigenetic Signature in Asthmatic Airways

16 Oct 2015

Abstract excerpt

RATIONALE: Epigenetic changes to airway cells have been proposed as important modulators of the effects of environmental exposures on airway diseases, yet no study to date has shown epigenetic responses to exposures in the airway that correlate with disease state. The type 2 cytokine IL-13 is a key mediator of allergic airway diseases, such as asthma, and is up-regulated in response to many asthma-promoting...

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PMID: 26474238
DOI: 10.1164/rccm.201506-1243oc

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