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Article

Early modulation of pro-inflammatory microglia by minocycline loaded nanoparticles confers long lasting protection after spinal cord injury.

Biomaterials - 1 Jan 2016

Papa Simonetta, Caron Ilaria, Erba Eugenio, Panini Nicolò, De Paola Massimiliano, Mariani Alessandro, Colombo Claudio, Ferrari Raffaele, Pozzer Diego, Zanier Elisa R, Pischiutta Francesca, Lucchetti Jacopo, Bassi Andrea, Valentini Gianluca, Simonutti Giulio, Rossi Filippo, Moscatelli Davide, Forloni Gianluigi, Veglianese Pietro

Abstract excerpt

Many efforts have been performed in order to understand the role of recruited macrophages in the progression of spinal cord injury (SCI). Different studies revealed a pleiotropic effect played by these cells associated to distinct phenotypes (M1 and M2), showing a predictable spatial and temporal distribution in the injured site after SCI. Differently, the role of activated microglia in injury progression has...

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Identifiers

PMID: 26474039
DOI: 10.1016/j.biomaterials.2015.10.015

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CCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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