The Genotype of the Donor for the (GT)n Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation.

doi:10.1371/journal.pone.0140454

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The Genotype of the Donor for the (GT)n Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation.

PloS one - 1 Jan 2015

Noriega Víctor, Martínez-Laperche Carolina, Buces Elena, Pion Marjorie, Sánchez-Hernández Noemí, Martín-Antonio Beatriz, Guillem Vicent, Bosch-Vizcaya Anna, Bento Leyre, González-Rivera Milagros, Balsalobre Pascual, Kwon Mi, Serrano David, Gayoso Jorge, de la Cámara Rafael, Brunet Salut, Rojas-Contreras Rafael, Nieto José B, Martínez Carmen, Gónzalez Marcos, Espigado Ildefonso, Vallejo Juan C, Sampol Antonia, Jiménez-Velasco Antonio, Urbano-Ispizua Alvaro, Solano Carlos, Gallardo David, Díez-Martín José L, Buño Ismael

Abstract excerpt

The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. Short alleles (≤(GT)15) for the (GT)n...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Genetic Association Studies

Share to Graft vs Host Disease

Share to Hematopoietic Stem Cell Transplantation

Share to Promoter Regions, Genetic

Share to Survival Analysis

Share to Tissue Donors

Share to Transplantation, Homologous

Source

Open in PubMed Open full text

Identifiers

PMID: 26473355
DOI: 10.1371/journal.pone.0140454
PMCID: PMC4608671

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Genotype of the Donor for the (GT)n Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation.PMID 26473355Read ↗

Genetic variants of FOXP3 influence graft survival in kidney transplant patients.Semantic proximity Read ↗

Influence of FOXP3 single-nucleotide polymorphism after allogeneic hematopoietic stem cell transplantation.Semantic proximity Read ↗

Effect of FOXP3 polymorphism on the clinical outcomes after allogeneic hematopoietic stem cell transplantation in pediatric acute leukemia patients.Semantic proximity Read ↗

Association of FOXP3 Single Nucleotide Polymorphisms With Clinical Outcomes After Allogenic Hematopoietic Stem Cell Transplantation.Semantic proximity Read ↗

Genetic polymorphism in FOXP3 gene: imbalance in regulatory T-cell role and development of human diseases.Semantic proximity Read ↗

Dissecting the role of the FOXP3 gene in the joint genetic susceptibility to autoimmune thyroiditis and diabetes: a genetic and functional analysis.Semantic proximity Read ↗

FOXP3 gene polymorphisms increase the risk of systemic lupus erythematosus in a Han Chinese population.Semantic proximity Read ↗

Genetic association of FOXP3 gene polymorphisms with allograft rejection in renal transplant patients.Semantic proximity Read ↗

Association of single-nucleotide polymorphisms in FOXP3 gene with systemic lupus erythematosus susceptibility: a case-control study.Semantic proximity Read ↗

The Role of FOXP3 in Human Cancers.Semantic proximity Read ↗

Frequency of CD4+FOXP3+ regulatory T-cells at early stages after HLA-mismatched allogeneic hematopoietic SCT predicts the incidence of acute GVHDSemantic proximity Read ↗

Monitoring of molecular profiling of regulatory T cell biomarkers by using non- invasive strategies to predict outcome in renal transplantationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.