Influence of FOXP3 single-nucleotide polymorphism after allogeneic hematopoietic stem cell transplantation.

doi:10.1007/s12185-024-03726-y

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Article

Influence of FOXP3 single-nucleotide polymorphism after allogeneic hematopoietic stem cell transplantation.

International journal of hematology - 1 May 2024

Kuroiwa Kai, Sato Misuzu, Narita Hinako, Okamura Reiko, Uesugi Yuka, Sasaki Yohei, Shimada Shotaro, Watanuki Megumi, Fujiwara Shun, Kawaguchi Yukiko, Arai Nana, Yanagisawa Kouji, Iezumi Keiichi, Hattori Norimichi

Abstract excerpt

The impact of FOXP3 single-nucleotide polymorphisms (SNP) on clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains poorly understood. We investigated the relationship between a FOXP3 SNP (rs3761548) and clinical outcomes in 91 patients with hematological malignancies after allo-HSCT. Multivariate analysis showed that risk of severe chronic graft-versus-host disease (cGVHD)...

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PMID: 38418747
DOI: 10.1007/s12185-024-03726-y

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