Article
Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization.
Scientific reports - 16 Oct 2015
Kurup Abhishek, Ravindranath Shreyas, Tran Tim, Keating Mark, Gascard Philippe, Valdevit Lorenzo, Tlsty Thea D, Botvinick Elliot L
Abstract excerpt
3D tissue culture models are utilized to study breast cancer and other pathologies because they better capture the complexity of in vivo tissue architecture compared to 2D models. However, to mimic the in vivo environment, the mechanics and geometry of the ECM must also be considered. Here, we studied the mechanical environment created in two 3D models, the overlay protocol (OP) and embedded protocol (EP)....
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