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Article

ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.

The EMBO journal - 1 Sept 2022

Kai FuiBoon, Ou Guanqing, Tourdot Richard W, Stashko Connor, Gaietta Guido, Swift Mark F, Volkmann Niels, Long Alexandra F, Han Yulong, Huang Hector H, Northey Jason J, Leidal Andrew M, Viasnoff Virgile, Bryant David M, Guo Wei, Wiita Arun P, Guo Ming, Dumont Sophie, Hanein Dorit, Radhakrishnan Ravi, Weaver Valerie M

Abstract excerpt

Patient-derived organoids and cellular spheroids recapitulate tissue physiology with remarkable fidelity. We investigated how engagement with a reconstituted basement membrane in three dimensions (3D) supports the polarized, stress resilient tissue phenotype of mammary epithelial spheroids. Cells interacting with reconstituted basement membrane in 3D had reduced levels of total and actin-associated filamin and...

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Identifiers

PMID: 35880301
DOI: 10.15252/embj.2021109205
PMCID: PMC9434103

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