Article
Association mapping by pooled sequencing identifies TOLL 11 as a protective factor against Plasmodium falciparum in Anopheles gambiae.
BMC genomics - 13 Oct 2015
Redmond Seth N, Eiglmeier Karin, Mitri Christian, Markianos Kyriacos, Guelbeogo Wamdaogo M, Gneme Awa, Isaacs Alison T, Coulibaly Boubacar, Brito-Fravallo Emma, Maslen Gareth, Mead Daniel, Niare Oumou, Traore Sekou F, Sagnon N'Fale, Kwiatkowski Dominic, Riehle Michelle M, Vernick Kenneth D
Abstract excerpt
BACKGROUND: The genome-wide association study (GWAS) techniques that have been used for genetic mapping in other organisms have not been successfully applied to mosquitoes, which have genetic characteristics of high nucleotide diversity, low linkage disequilibrium, and complex population stratification that render population-based GWAS essentially unfeasible at realistic sample size and marker density. METHODS:...
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