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Article

Identification of three single nucleotide polymorphisms in Anopheles gambiae immune signaling genes that are associated with natural Plasmodium falciparum infection.

Malaria journal - 11 Jun 2010

Horton Ashley A, Lee Yoosook, Coulibaly Cheick A, Rashbrook Vanessa K, Cornel Anthony J, Lanzaro Gregory C, Luckhart Shirley

Abstract excerpt

BACKGROUND: Laboratory studies have demonstrated that a variety of immune signaling pathways regulate malaria parasite infection in Anopheles gambiae, the primary vector species in Africa. METHODS: To begin to understand the importance of these associations under natural conditions, an association mapping approach was adopted to determine whether single nucleotide polymorphisms (SNPs) in selected immune signaling...

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Identifiers

PMID: 20540770
DOI: 10.1186/1475-2875-9-160
PMCID: PMC2896950

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