Article
Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region.
Science (New York, N.Y.) - 28 Apr 2006
Riehle Michelle M, Markianos Kyriacos, Niaré Oumou, Xu Jiannong, Li Jun, Touré Abdoulaye M, Podiougou Belco, Oduol Frederick, Diawara Sory, Diallo Mouctar, Coulibaly Boubacar, Ouatara Ahmed, Kruglyak Leonid, Traoré Sékou F, Vernick Kenneth D
Abstract excerpt
We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci...
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