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Article

Contribution of a mutational hot spot to hemoglobin adaptation in high-altitude Andean house wrens.

Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 2015

Galen Spencer C, Natarajan Chandrasekhar, Moriyama Hideaki, Weber Roy E, Fago Angela, Benham Phred M, Chavez Andrea N, Cheviron Zachary A, Storz Jay F, Witt Christopher C

Abstract excerpt

A key question in evolutionary genetics is why certain mutations or certain types of mutation make disproportionate contributions to adaptive phenotypic evolution. In principle, the preferential fixation of particular mutations could stem directly from variation in the underlying rate of mutation to function-altering alleles. However, the influence of mutation bias on the genetic architecture of phenotypic...

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Identifiers

PMID: 26460028
DOI: 10.1073/pnas.1507300112
PMCID: PMC4653164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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