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Article

Epistasis among adaptive mutations in deer mouse hemoglobin.

Science (New York, N.Y.) - 14 Jun 2013

Natarajan Chandrasekhar, Inoguchi Noriko, Weber Roy E, Fago Angela, Moriyama Hideaki, Storz Jay F

Abstract excerpt

Epistatic interactions between mutant sites in the same protein can exert a strong influence on pathways of molecular evolution. We performed protein engineering experiments that revealed pervasive epistasis among segregating amino acid variants that contribute to adaptive functional variation in...

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Identifiers

PMID: 23766324
DOI: 10.1126/science.1236862
PMCID: PMC4409680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23766324-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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