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Article

The HLA-G cycle provides for both NK tolerance and immunity at the maternal–fetal interface

12 Oct 2015

Abstract excerpt

The interaction of noncytotoxic decidual natural killer cells (dNK) and extravillous trophoblasts (EVT) at the maternal-fetal interface was studied. Confocal microscopy revealed that many dNK interact with a single large EVT. Filamentous projections from EVT enriched in HLA-G were shown to contact dNK, and may represent the initial stage of synapse formation. As isolated, 2.5% of dNK contained surface HLA-G....

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Share to Ectopic Pregnancy Diagnosis and Management
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Identifiers

PMID: 26460007
DOI: 10.1073/pnas.1517724112

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