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The Molecular Mechanisms of HLA-G Regulatory Function on Immune Cells during Early Pregnancy

3 Aug 2023

Abstract excerpt

Human leukocyte antigen-G (HLA-G) is a non-classical human major histocompatibility complex (MHC-I) molecule with the membrane-bound and soluble types. HLA-G is primarily expressed by extravillous cytotrophoblast cells located at the maternal-fetal interface during pregnancy and is essential in establishing immune tolerance. This review provides a comprehensive understanding of the multiple molecular mechanisms...

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PMID: 37627278
DOI: 10.3390/biom13081213

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