Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis).

doi:10.1186/s13075-015-0796-x

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Article

Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis).

Arthritis research & therapy - 13 Oct 2015

López-Mejías Raquel, Genre Fernanda, Remuzgo-Martínez Sara, Pérez Belén Sevilla, Castañeda Santos, Llorca Javier, Ortego-Centeno Norberto, Ubilla Begoña, Mijares Verónica, Pina Trinitario, Calvo-Río Vanesa, Palmou Natalia, Miranda-Filloy José A, Parejo Antonio Navas, Argila Diego, Sánchez-Pérez Javier, Rubio Esteban, Luque Manuel León, Blanco-Madrigal Juan María, Galíndez-Aguirregoikoa Eva, Ocejo-Vinyals J Gonzalo, Martín Javier, Blanco Ricardo, González-Gay Miguel A

Abstract excerpt

INTRODUCTION: To determine whether the PTPN22 (protein tyrosine phosphatase nonreceptor 22)/CSK (c-src tyrosine kinase) pathway is implicated in the susceptibility and clinical heterogeneity of Henoch-Schönlein purpura (HSP) in the largest series of Caucasian HSP patients ever assessed for genetic studies. METHODS: A set of 329 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology...

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Identifiers

PMID: 26458874
DOI: 10.1186/s13075-015-0796-x
PMCID: PMC4603645

Genes

CSK
PTPN22

Variants

rs34933034
rs34933034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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