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Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin.

Chemistry & biology - 22 Oct 2015

Painter Ronald E, Adam Gregory C, Arocho Marta, DiNunzio Edward, Donald Robert G K, Dorso Karen, Genilloud Olga, Gill Charles, Goetz Michael, Hairston Nichelle N, Murgolo Nicholas, Nare Bakela, Olsen David B, Powles Maryann, Racine Fred, Su Jing, Vicente Francisca, Wisniewski Douglas, Xiao Li, Hammond Milton, Young Katherine

Abstract excerpt

Resistance to existing classes of antibiotics drives the need for discovery of novel compounds with unique mechanisms of action. Nargenicin A1, a natural product with limited antibacterial spectrum, was rediscovered in a whole-cell antisense assay. Macromolecular labeling in both Staphylococcus aureus and an Escherichia coli tolC efflux mutant revealed selective inhibition of DNA replication not due to gyrase or...

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PMID: 26456734
DOI: 10.1016/j.chembiol.2015.08.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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