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Article

Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma.

Oncotarget - 13 Oct 2015

Piva Francesco, Giulietti Matteo, Occhipinti Giulia, Santoni Matteo, Massari Francesco, Sotte Valeria, Iacovelli Roberto, Burattini Luciano, Santini Daniele, Montironi Rodolfo, Cascinu Stefano, Principato Giovanni

Abstract excerpt

Clear cell Renal Cell Carcinoma (ccRCC) is due to loss of von Hippel-Lindau (VHL) gene and at least one out of three chromatin regulating genes BRCA1-associated protein-1 (BAP1), Polybromo-1 (PBRM1) and Set domain-containing 2 (SETD2). More than 350, 700 and 500 mutations are known respectively for BAP1, PBRM1 and SETD2 genes. Each variation damages these genes with different severity levels. Unfortunately for...

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Identifiers

PMID: 26452128
DOI: 10.18632/oncotarget.5147
PMCID: PMC4741666

Genes

BAP1
PBRM1
SETD2
BRCA1
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma.PMID 26452128Read ↗

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