Article
Leptin signal transduction underlies the differential metabolic response of LEW and WKY rats to cafeteria diet.
Journal of molecular endocrinology - 1 Jan 2016
Martínez-Micaelo N, González-Abuín N, Ardévol A, Pinent M, Petretto E, Behmoaras J, Blay M
Abstract excerpt
Although the effect of genetic background on obesity-related phenotypes is well established, the main objective of this study is to determine the phenotypic responses to cafeteria diet (CAF) of two genetically distinct inbred rat strains and give insight into the molecular mechanisms that might be underlying. Lewis (LEW) and Wistar-Kyoto (WKY) rats were fed with either a standard or a CAF diet. The effects of the...
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