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Article

Combinational Effect of CYP3A5 and MDR-1 Polymorphisms on Tacrolimus Pharmacokinetics in Liver Transplant Patients.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation - 1 Oct 2015

Buendía Jefferson Antonio, Otamendi Esteban, Kravetz María Cecilia, Cairo Fernando, Ruf Andrés, de Davila María, Powazniak Yanina, Nafissi Julieta, Lazarowski Alberto, Bramuglia Guillermo, Villamil Federico

Abstract excerpt

OBJECTIVES: Previous studies have reported reduced tacrolimus dose-adjusted exposure in individuals expressing the CYP3A5*1 allele (reference single nucleotide polymorphism identification number 776746). However, results on patients from South America are scarce. The objective of this study was to investigate the influence of CYP3A5 and MDR1 allelic variants and their correlation on the pharmacokinetics of...

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Identifiers

PMID: 26450467

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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