Article
Genetic polymorphisms of the human cytomegalovirus UL144 gene in colorectal cancer and its association with clinical outcome.
The Journal of general virology - 1 Dec 2015
Chen Hsin-Pai, Jiang Jeng-Kai, Chan Chia-Hao, Teo Wan-Huai, Yang Chih-Yung, Chen Yen-Chung, Chou Teh-Ying, Lin Chi-Hung, Chan Yu-Jiun
Abstract excerpt
Human cytomegalovirus (HCMV) has been increasingly detected in colorectal cancer (CRC), and genetic polymorphisms in HCMV affect its pathogenesis. This study aimed to investigate HCMV genetic polymorphisms in CRC and its correlation with the clinical outcomes. We performed PCR and sequencing of a viral immunomodulatory gene, UL144, in clinical isolates and CRC specimens. The nucleotide and amino acid sequences...
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