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Article

DNA methylation aberrations rather than polymorphisms of FZD3 gene increase the risk of spina bifida in a high-risk region for neural tube defects.

Birth defects research. Part A, Clinical and molecular teratology - 1 Jan 2015

Shangguan Shaofang, Wang Li, Chang Shaoyan, Lu Xiaoling, Wang Zhen, Wu Lihua, Wang Jianhua, Wang Xiuwei, Guan Zhen, Bao Yihua, Zhao Huizhi, Zou Jizhen, Niu Bo, Zhang Ting

Abstract excerpt

BACKGROUND: Animal models of neural tube defects (NTDs) have indicated roles for the Fzd3 gene and the planar cell polarity signaling pathway in convergent extension. We investigated the involvement of FZD3 in genetic and epigenetic mechanisms associated with human NTDs, especially spina bifida. We explored the effects of variants spanning the FZD3 gene in NTDs and examined the role of aberrant methylation of the...

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Identifiers

PMID: 25131656
DOI: 10.1002/bdra.23285

Genes

FZD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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