M <scp>olecular</scp> D <scp>efects in</scp> H <scp>uman</scp> S <scp>evere</scp> C <scp>ombined</scp> I <scp>mmunodeficiency and</scp> A <scp>pproaches to</scp> I <scp>mmune</scp> R <scp>econstitution</scp>

doi:10.1146/annurev.immunol.22.012703.104614

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M <scp>olecular</scp> D <scp>efects in</scp> H <scp>uman</scp> S <scp>evere</scp> C <scp>ombined</scp> I <scp>mmunodeficiency and</scp> A <scp>pproaches to</scp> I <scp>mmune</scp> R <scp>econstitution</scp>

19 Mar 2004

Abstract excerpt

Mutations in nine different genes have been found to cause the human severe combined immunodeficiency syndrome. The products of three of the genes--IL-2RG, Jak3, and IL-7R alpha--are components of cytokine receptors, and the products of three more-RAG1, RAG2, and Artemis-are essential for effecting antigen receptor gene rearrangement. Additionally, a deficiency of CD3 delta, a component of the T-cell antigen...

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PMID: 15032591
DOI: 10.1146/annurev.immunol.22.012703.104614

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