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Article

FTO Is Associated with Aortic Valve Stenosis in a Gender Specific Manner of Heterozygote Advantage: A Population-Based Case-Control Study.

PloS one - 1 Jan 2015

Thron Cindy, Akhyari Payam, Godehardt Erhard, Lichtenberg Artur, Rüther Ulrich, Seehaus Stefanie

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) within the Fat mass and obesity associated (FTO) gene have been linked with increased body weight. However, the data on an association of FTO with cardiovascular diseases remains conflicting. Therefore, we ascertained whether FTO is associated with aortic valve stenosis (AVS), one of the most frequent cardiovascular diseases in the Western world. METHODS AND...

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Identifiers

PMID: 26431034
DOI: 10.1371/journal.pone.0139419
PMCID: PMC4592246

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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