Article
The fat mass and obesity-associated (FTO) gene variant rs9939609 predicts long-term incidence of cardiovascular disease and related death independent of the traditional risk factors.
Annals of medicine - 1 Jan 2015
Äijälä Meiju, Ronkainen Justiina, Huusko Tuija, Malo Elina, Savolainen Eeva-Riitta, Savolainen Markku J, Salonurmi Tuire, Bloigu Risto, Kesäniemi Y Antero, Ukkola Olavi
Abstract excerpt
OBJECTIVE AND METHODS: The impact of the rs9939609 FTO variant on cardiovascular events was investigated in the 19-year follow-up of subjects recruited to the OPERA study. RESULTS: A total of 212 cardiovascular disease (CVD) and 152 coronary heart disease (CHD) events or deaths occurred during follow-up. The logistic regression analysis revealed that among the AA genotype the incidence of CHD (OR 1.905; 95% CI...
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