Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.

doi:10.1038/ni.3443

Article

Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.

Nature immunology - 1 Jun 2016

Silver Jonathan S, Kearley Jennifer, Copenhaver Alan M, Sanden Caroline, Mori Michiko, Yu Li, Pritchard Gretchen Harms, Berlin Aaron A, Hunter Christopher A, Bowler Russell, Erjefalt Jonas S, Kolbeck Roland, Humbles Alison A

Abstract excerpt

Innate lymphoid cells (ILCs) are critical mediators of mucosal immunity, and group 1 ILCs (ILC1 cells) and group 3 ILCs (ILC3 cells) have been shown to be functionally plastic. Here we found that group 2 ILCs (ILC2 cells) also exhibited phenotypic plasticity in response to infectious or noxious agents, characterized by substantially lower expression of the transcription factor GATA-3 and a concomitant switch to...

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Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.

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