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Article

Germline variants in cancer genes in high-risk non-BRCA patients from Puerto Rico.

Scientific reports - 28 Nov 2019

Dutil Julie, Teer Jamie K, Golubeva Volha, Yoder Sean, Tong Wei Lue, Arroyo Nelly, Karam Rachid, Echenique Miguel, Matta Jaime L, Monteiro Alvaro N

Abstract excerpt

Inherited pathogenic variants in genes that confer moderate to high risk of breast cancer may explain up to 50% of familial breast cancer. This study aimed at identifying inherited pathogenic variants in breast cancer cases from Puerto Rico that were not linked to BRCA1 or BRCA2. Forty-eight breast cancer patients that met the clinical criteria for BRCA testing but had received a negative BRCA1/2 result were...

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Identifiers

PMID: 31780696
DOI: 10.1038/s41598-019-54170-6
PMCID: PMC6882826

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