Article
Analyzing the potential for incorrect haplotype calls with different pharmacogenomic assays in different populations: a simulation based on 1000 Genomes data.
Pharmacogenomics - 1 Jan 2015
Samwald Matthias, Blagec Kathrin, Hofer Sebastian, Freimuth Robert R
Abstract excerpt
AIM: Many currently available pharmacogenomic assays and algorithms interrogate a set of 'tag' polymorphisms for inferring haplotypes. We wanted to test the accuracy of such haplotype inferences across different populations. MATERIALS & METHODS: We simulated haplotype inferences made by existing pharmacogenomic assays for seven important pharmacogenes based on full genome data of 2504 persons in the 1000 Genomes...
Topics
- Algorithms
- Alleles
- Databases, Genetic
- Gene Frequency
- Haplotypes
- Humans
- Pharmacogenetics
- Polymorphism, Genetic
- Population Groups
- Terminology as Topic