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Article

Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression.

Oncotarget - 20 Oct 2015

Wu Mingsong, Si Shuhui, Li Yan, Schoen Susan, Xiao Guang-Qian, Li Xueying, Teh Bin Tean, Wu Guan, Chen Jindong

Abstract excerpt

Deficiency of tumor suppressor FLCN leads to the activation of the mTOR signaling pathway in human BHD-associated renal cell carcinomas (RCC). We have previously developed a renal distal tubule-collecting duct-Henle's loop-specific Flcn knockout (KO) mouse model (Flcnflox/flox/Ksp-Cre). This mouse model can only survive for three weeks after birth due to the development of polycystic kidney and uremia. Whether...

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Source

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Identifiers

PMID: 26418749
DOI: 10.18632/oncotarget.5018
PMCID: PMC4741728

Genes

FLCN

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