Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys.

doi:10.1093/jnci/djm288

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Article

Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys.

Journal of the National Cancer Institute - 16 Jan 2008

Baba Masaya, Furihata Mutsuo, Hong Seung-Beom, Tessarollo Lino, Haines Diana C, Southon Eileen, Patel Vishal, Igarashi Peter, Alvord W Gregory, Leighty Robert, Yao Masahiro, Bernardo Marcelino, Ileva Lilia, Choyke Peter, Warren Michelle B, Zbar Berton, Linehan W Marston, Schmidt Laura S

Abstract excerpt

BACKGROUND: Patients with Birt-Hogg-Dubé (BHD) syndrome harbor germline mutations in the BHD tumor suppressor gene that are associated with an increased risk for kidney cancer. BHD encodes folliculin, a protein that may interact with the energy- and nutrient-sensing 5'-AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) signaling pathways. METHODS: We used recombineering methods to generate...

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PMID: 18182616
DOI: 10.1093/jnci/djm288
PMCID: PMC2704336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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