Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal.

doi:10.1371/journal.pmed.1001880

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Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal.

PLoS medicine - 1 Sept 2015

Cohen Keira A, Abeel Thomas, Manson McGuire Abigail, Desjardins Christopher A, Munsamy Vanisha, Shea Terrance P, Walker Bruce J, Bantubani Nonkqubela, Almeida Deepak V, Alvarado Lucia, Chapman Sinéad B, Mvelase Nomonde R, Duffy Eamon Y, Fitzgerald Michael G, Govender Pamla, Gujja Sharvari, Hamilton Susanna, Howarth Clinton, Larimer Jeffrey D, Maharaj Kashmeel, Pearson Matthew D, Priest Margaret E, Zeng Qiandong, Padayatchi Nesri, Grosset Jacques, Young Sarah K, Wortman Jennifer, Mlisana Koleka P, O'Donnell Max R, Birren Bruce W, Bishai William R, Pym Alexander S, Earl Ashlee M

Abstract excerpt

BACKGROUND: The continued advance of antibiotic resistance threatens the treatment and control of many infectious diseases. This is exemplified by the largest global outbreak of extensively drug-resistant (XDR) tuberculosis (TB) identified in Tugela Ferry, KwaZulu-Natal, South Africa, in 2005 that continues today. It is unclear whether the emergence of XDR-TB in KwaZulu-Natal was due to recent inadequacies in TB...

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PMID: 26418737
DOI: 10.1371/journal.pmed.1001880
PMCID: PMC4587932

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