Article
Resistance to serine in Bacillus subtilis: identification of the serine transporter YbeC and of a metabolic network that links serine and threonine metabolism.
Environmental microbiology - 1 Sept 2020
Klewing Anika, Koo Byoung-Mo, Krüger Larissa, Poehlein Anja, Reuß Daniel, Daniel Rolf, Gross Carol A, Stülke Jörg
Abstract excerpt
The Gram-positive bacterium Bacillus subtilis uses serine not only as a building block for proteins but also as an important precursor in many anabolic reactions. Moreover, a lack of serine results in the initiation of biofilm formation. However, excess serine inhibits the growth of B. subtilis. To unravel the underlying mechanisms, we isolated suppressor mutants that can tolerate toxic serine concentrations by...
Topics
- Amino Acid Transport Systems
- Bacillus subtilis
- Bacterial Proteins
- Drug Resistance, Bacterial
- Escherichia coli
- Metabolic Networks and Pathways
- Mutation
- Serine
- Threonine