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Mechanisms Underlying Testicular Damage and Dysfunction in Mice With Partial IGF-1 Deficiency and the Effectiveness of IGF-1 Replacement Therapy.

Urology - 1 Dec 2015

Castilla-Cortázar Inma, Gago Alberto, Muñoz Úrsula, Ávila-Gallego Elena, Guerra-Menéndez Lucía, Sádaba María Cruz, García-Magariño Mariano, Olleros Santos-Ruiz María, Aguirre G A, Puche Juan Enrique

Abstract excerpt

OBJECTIVE: To determine whether insulin-like growth factor (IGF-1) deficiency can cause testicular damage and to examine changes of the testicular morphology and testicular function-related gene expression caused by IGF-1 deficiency. Therefore, this study aims to determine the benefits of low doses of IGF-1 and to explore the mechanisms underlying the IGF-1 replacement therapy. MATERIALS AND METHODS: A murine...

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PMID: 26408501
DOI: 10.1016/j.urology.2015.09.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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