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Article

Extraordinary Diversity of Immune Response Proteins among Sea Urchins: Nickel-Isolated Sp185/333 Proteins Show Broad Variations in Size and Charge.

PloS one - 1 Jan 2015

Sherman Lauren S, Schrankel Catherine S, Brown Kristy J, Smith L Courtney

Abstract excerpt

Effective protection against pathogens requires the host to produce a wide range of immune effector proteins. The Sp185/333 gene family, which is expressed by the California purple sea urchin Strongylocentrotus purpuratus in response to bacterial infection, encodes a highly diverse repertoire of anti-pathogen proteins. A subset of these proteins can be isolated by affinity to metal ions based on multiple...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26406912
DOI: 10.1371/journal.pone.0138892
PMCID: PMC4583492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Extraordinary Diversity of Immune Response Proteins among Sea Urchins: Nickel-Isolated Sp185/333 Proteins Show Broad Variations in Size and Charge.PMID 26406912Read ↗

Multitasking Immune Sp185/333 Protein, rSpTransformer-E1, and Its Recombinant Fragments Undergo Secondary Structural Transformation upon Binding Targets.Semantic proximity Read ↗

The Sp185/333 immune response genes and proteins are expressed in cells dispersed within all major organs of the adult purple sea urchin.Semantic proximity Read ↗

SpTransformer proteins from the purple sea urchin opsonize bacteria, augment phagocytosis, and retard bacterial growth.Semantic proximity Read ↗

An Sp185/333 gene cluster from the purple sea urchin and putative microsatellite-mediated gene diversification.Semantic proximity Read ↗

Characterization of the highly variable immune response gene family, He185/333, in the sea urchin, Heliocidaris erythrogramma.Semantic proximity Read ↗

Extraordinary diversity among members of the large gene family, 185/333, from the purple sea urchin, Strongylocentrotus purpuratus.Semantic proximity Read ↗

Unexpected diversity displayed in cDNAs expressed by the immune cells of the purple sea urchin, Strongylocentrotus purpuratus.Semantic proximity Read ↗

Distinctive expression patterns of 185/333 genes in the purple sea urchin, Strongylocentrotus purpuratus: an unexpectedly diverse family of transcripts in response to LPS, beta-1,3-glucan, and dsRNA.Semantic proximity Read ↗

The 185/333 gene family is a rapidly diversifying host-defense gene cluster in the purple sea urchin Strongylocentrotus purpuratus.Semantic proximity Read ↗

Diversification of innate immune genes: lessons from the purple sea urchin.Semantic proximity Read ↗

Sequence variations in 185/333 messages from the purple sea urchin suggest posttranscriptional modifications to increase immune diversity.Semantic proximity Read ↗

Short tandem repeats, segmental duplications, gene deletion, and genomic instability in a rapidly diversified immune gene family.Semantic proximity Read ↗

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