Article
Diversification of innate immune genes: lessons from the purple sea urchin.
Disease models & mechanisms - 1 Jan 2000
Smith L Courtney
Abstract excerpt
Pathogen diversification can alter infection virulence, which in turn drives the evolution of host immune diversification, resulting in countermeasures for survival in this arms race. Somatic recombination of the immunoglobulin gene family members is a very effective mechanism to diversify antibodies and T-cell receptors that function in the adaptive immune system. Although mechanisms to diversify innate immune...
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