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Article

Insulin regulation of heart function in aging fruit flies.

Nature genetics - 1 Dec 2004

Wessells Robert J, Fitzgerald Erin, Cypser James R, Tatar Marc, Bodmer Rolf

Abstract excerpt

Insulin-IGF receptor (InR) signaling has a conserved role in regulating lifespan, but little is known about the genetic control of declining organ function. Here, we describe progressive changes of heart function in aging fruit flies: from one to seven weeks of a fly's age, the resting heart rate decreases and the rate of stress-induced heart failure increases. These age-related changes are minimized or absent in...

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PMID: 15565107
DOI: 10.1038/ng1476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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