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Telomeres and replicative cellular aging of the human placenta and chorioamniotic membranes

4 Mar 2021

Abstract excerpt

Recent hypotheses propose that the human placenta and chorioamniotic membranes (CAMs) experience telomere length (TL)-mediated senescence. These hypotheses are based on mean TL (mTL) measurements, but replicative senescence is triggered by short and dysfunctional telomeres, not mTL. We measured short telomeres by a vanguard method, the Telomere shortest length assay, and telomere-dysfunction-induced DNA damage...

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Share to Pregnancy and preeclampsia studies
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PMID: 33664422
DOI: 10.1038/s41598-021-84728-2

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