Article
The C-terminus hot spot region helps in the fibril formation of bacteriophage-associated hyaluronate lyase (HylP2).
Scientific reports - 23 Sept 2015
Shukla Harish, Singh Sudhir Kumar, Singh Amit Kumar, Mitra Kalyan, Akhtar Md Sohail
Abstract excerpt
The bacteriophage encoded hyaluronate lyases (HylP and HylP2) degrade hyaluronan and other glycosaminoglycans. HylP2 forms a functional fibril under acidic conditions in which its N-terminus is proposed to form the fibrillar core, leading to nucleation and acceleration of fibril formation. Here we report the presence of a hot spot region (A144GVVVY149) towards the carboxy terminus of HylP2, essential for the...
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