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Article

Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9.

The Journal of biological chemistry - 17 Jul 2009

Reitinger Stephan, Müllegger Johannes, Greiderer Brigitte, Nielsen Jens Erik, Lepperdinger Günter

Abstract excerpt

Hyaluronidases from diverse species and sources have different pH optima. Distinct mechanisms with regard to dynamic structural changes, which control hyaluronidase activity at varying pH, are unknown. Human serum hyaluronidase 1 (HYAL1) is active solely below pH 5.1. Here we report the design of a HYAL1 variant that degrades hyaluronan up to pH 5.9. Besides highly conserved residues in close proximity of the...

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Identifiers

PMID: 19478093
DOI: 10.1074/jbc.C109.004358
PMCID: PMC2740539

Genes

HYAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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