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Article

Circadian Clock Gene Plays a Key Role on Ovarian Cycle and Spontaneous Abortion

1 Jan 2015

Abstract excerpt

BACKGROUND/AIMS: Circadian locomotor output cycles protein kaput (CLOCK) plays a key role in maintaining circadian rhythms and activation of downstream elements. However, its function on human female reproductive system remains unknown. METHODS: To investigate the potential role of CLOCK, CLOCK-shRNAs were transfected into mouse 129 ES cells or injected into the ovaries of adult female mice. Western blotting was...

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PMID: 26390085
DOI: 10.1159/000430218

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