Repair of large segmental bone defects: BMP-2 gene activated muscle grafts vs. autologous bone grafting

Abstract excerpt

BACKGROUND: Common cell based strategies for the treatment of osseous defects require the isolation and expansion of autologous cells. Since this makes such approaches time-consuming and expensive, we developed a novel expedited technology creating gene activated muscle grafts. We have previously shown that large segmental bone defects in rats can be regenerated by implantation of muscle tissue fragments...

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