Article
High prevalence of the MYD88 mutation in testicular lymphoma: Immunohistochemical and genetic analyses.
Pathology international - 1 Oct 2015
Oishi Naoki, Kondo Tetsuo, Nakazawa Tadao, Mochizuki Kunio, Tanioka Fumihiko, Oyama Toshio, Yamamoto Tomoko, Iizuka Junpei, Tanabe Kazunari, Shibata Noriyuki, Kirito Keita, Katoh Ryohei
Abstract excerpt
The activating mutation of MYD88 has been identified in diffuse large B-cell lymphoma (DLBCL). We investigated the mutational status and both the gene amplification and protein expression of MYD88 in 23 cases of testicular DLBCL. To detect the MYD88 mutations, we employed the allele-specific PCR and Sanger sequencing. MYD88 gene amplification and protein expression were analyzed by quantitative PCR and by...
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