Article
MYD88, CD79B, and CARD11 gene mutations in CD5-positive diffuse large B-cell lymphoma.
Cancer - 1 Apr 2017
Takeuchi Toshifumi, Yamaguchi Motoko, Kobayashi Kyoko, Miyazaki Kana, Tawara Isao, Imai Hiroshi, Ono Ryoichi, Nosaka Tetsuya, Tanaka Kyosuke, Katayama Naoyuki
Abstract excerpt
BACKGROUND: CD5-positive (CD5+ ) diffuse large B-cell lymphoma (DLBCL) is characterized by frequent central nervous system recurrence and a predominant activated B-cell-like nature. Primary DLBCL in sanctuary sites (DLBCL-SS) also demonstrates these features, and >70% of patients harbor myeloid differentiation primary response 88 (MYD88) (L265P) and CD79B mutations. The objective of the current study was to...
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