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Article

Pressure-induced structural transition of mature HIV-1 protease from a combined NMR/MD simulation approach.

Proteins - 1 Dec 2015

Roche Julien, Louis John M, Bax Ad, Best Robert B

Abstract excerpt

We investigate the pressure-induced structural changes in the mature human immunodeficiency virus type 1 protease dimer, using residual dipolar coupling (RDC) measurements in a weakly oriented solution. (1)DNH RDCs were measured under high-pressure conditions for an inhibitor-free PR and an inhibitor-bound complex, as well as for an inhibitor-free multidrug resistant protease bearing 20 mutations (PR20). While...

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Identifiers

PMID: 26385843
DOI: 10.1002/prot.24931
PMCID: PMC4715683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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